Over-pressurized bioreactors: application to microbial cell cultures.

Dynamic Simulation and Control of Microbial Cell Population in Continuous Bioreactors

Application of immobilized microbial cells in biological treatment of contaminated effluent with aromatic compounds: a review article

Background and Objective: Bioremediation of contaminants by living microorganisms is a favorable method for elimination or degradation of pollutants to less harmful substances. In the recent decades, cell immobilization technique has been applied to improve biodegradation efficiency and also overcome to free cells disadvantages. The purpose of this review article is to investigate the applicati...

High cell density cultivation of recombinant yeasts and bacteria under non-pressurized and pressurized conditions in stirred tank bioreactors.

This study demonstrates the applicability of pressurized stirred tank bioreactors for oxygen transfer enhancement in aerobic cultivation processes. The specific power input and the reactor pressure was employed as process variable. As model organism Escherichia coli, Arxula adeninivorans, Saccharomyces cerevisiae and Corynebacterium glutamicum were cultivated to high cell densities. By applying...

A novel process-based model of microbial growth: self-inhibition in Saccharomyces cerevisiae aerobic fed-batch cultures

BACKGROUND Microbial population dynamics in bioreactors depend on both nutrients availability and changes in the growth environment. Research is still ongoing on the optimization of bioreactor yields focusing on the increase of the maximum achievable cell density. RESULTS A new process-based model is proposed to describe the aerobic growth of Saccharomyces cerevisiae cultured on glucose as ca...

"Intelligent" descriptions of microbial kinetics in finitely dispersed bioreactors: neural and cybernetic models for PHB biosynthesis by Ralstonia eutropha

BACKGROUND For many microbial processes, the complexity of the metabolisms and the responses to transient and realistic conditions are difficult to capture in mechanistic models. The cells seem to have an innate intelligence that enables them to respond optimally to environmental changes. Some "intelligent" models have therefore been proposed and compared with a mechanistic model for fed-batch ...